The immunoproteasome and thymoproteasome: functions, evolution and human disease
Nature immunology, 2018•nature.com
The basic principle of adaptive immunity is to strictly discriminate between self and non-self,
and a central challenge to overcome is the enormous variety of pathogens that might be
encountered. In cell-mediated immunity, immunological discernment takes place at a
molecular or cellular level. Central to both mechanisms of discernment is the generation of
antigenic peptides associated with MHC class I molecules, which is achieved by a
proteolytic complex called the proteasome. To adequately accomplish the discrimination …
and a central challenge to overcome is the enormous variety of pathogens that might be
encountered. In cell-mediated immunity, immunological discernment takes place at a
molecular or cellular level. Central to both mechanisms of discernment is the generation of
antigenic peptides associated with MHC class I molecules, which is achieved by a
proteolytic complex called the proteasome. To adequately accomplish the discrimination …
Abstract
The basic principle of adaptive immunity is to strictly discriminate between self and non-self, and a central challenge to overcome is the enormous variety of pathogens that might be encountered. In cell-mediated immunity, immunological discernment takes place at a molecular or cellular level. Central to both mechanisms of discernment is the generation of antigenic peptides associated with MHC class I molecules, which is achieved by a proteolytic complex called the proteasome. To adequately accomplish the discrimination between self and non-self that is essential for adaptive immunity and self-tolerance, two proteasome subtypes have evolved via gene duplication: the immunoproteasome and the thymoproteasome. In this Review, we describe various aspects of these immunity-dedicated proteasomes, from their discovery to recent findings.
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