Pathogenic CD8+ T cells in experimental cerebral malaria
SW Howland, C Claser, CM Poh, SY Gun… - Seminars in …, 2015 - Springer
Seminars in immunopathology, 2015•Springer
Cerebral malaria (CM) is one the major complications occurring during malaria infection.
The mechanisms leading to this syndrome are still not completely understood. Although it is
clear that parasite sequestration is the key initiation factor, the downstream pathological
processes are still highly debated. The experimental cerebral malaria (ECM) model, in
which susceptible mice are infected with Plasmodium berghei ANKA, has led to the
identification of CD8+ T cells as the major mediator of ECM death. In this review, we discuss …
The mechanisms leading to this syndrome are still not completely understood. Although it is
clear that parasite sequestration is the key initiation factor, the downstream pathological
processes are still highly debated. The experimental cerebral malaria (ECM) model, in
which susceptible mice are infected with Plasmodium berghei ANKA, has led to the
identification of CD8+ T cells as the major mediator of ECM death. In this review, we discuss …
Abstract
Cerebral malaria (CM) is one the major complications occurring during malaria infection. The mechanisms leading to this syndrome are still not completely understood. Although it is clear that parasite sequestration is the key initiation factor, the downstream pathological processes are still highly debated. The experimental cerebral malaria (ECM) model, in which susceptible mice are infected with Plasmodium berghei ANKA, has led to the identification of CD8+ T cells as the major mediator of ECM death. In this review, we discuss the recent advances and future developments in the understanding of the role of CD8+ T cells in CM.
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