[HTML][HTML] A novel sulfonylurea receptor forms with BIR (Kir6. 2) a smooth muscle type ATP-sensitive K+ channel

S Isomoto, C Kondo, M Yamada, S Matsumoto… - Journal of Biological …, 1996 - ASBMB
We have isolated a cDNA encoding a novel isoform of the sulfonylurea receptor from a
mouse heart cDNA library. Coexpression of this isoform and BIR (Kir6. 2) in a mammalian
cell line elicited ATP-sensitive K+(K ATP) channel currents. The channel was effectively
activated by both diazoxide and pinacidil, which is the feature of smooth muscle K ATP
channels. Sequence analysis indicated that this clone is a variant of cardiac type
sulfonylurea receptor (SUR2). The 42 amino acid residues located in the carboxyl-terminal …