[HTML][HTML] Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins

EL Shelton, GK Singh, CG Nichols - Seminars in perinatology, 2018 - Elsevier
Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease
systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet,
prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by
imperfect therapies and wide variations in treatment strategy. There are few pharmacology-
based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for
maintaining DA patency (PGE 1) as is needed to facilitate corrective surgery for ductus …