[HTML][HTML] Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets …
N Inagaki, Y Tsuura, N Namba, K Masuda… - Journal of Biological …, 1995 - ASBMB
ATP-sensitive K+(K ATP) channels play a crucial role in coupling metabolic energy to the
membrane potential of cells. We have isolated a cDNA encoding a novel member (uK ATP-
1) of the inward rectifier K+ channel family from a rat pancreatic islet cDNA library. Rat uK
ATP-1 is a 424-amino acid residue protein (M r= 47,960). Electrophysiological studies of uK
ATP-1 expressed in Xenopus laevis oocytes show that uK ATP-1 is a weak rectifier and is
blocked with Ba 2+ ions. Single-channel patch clamp study of clonal human kidney …
membrane potential of cells. We have isolated a cDNA encoding a novel member (uK ATP-
1) of the inward rectifier K+ channel family from a rat pancreatic islet cDNA library. Rat uK
ATP-1 is a 424-amino acid residue protein (M r= 47,960). Electrophysiological studies of uK
ATP-1 expressed in Xenopus laevis oocytes show that uK ATP-1 is a weak rectifier and is
blocked with Ba 2+ ions. Single-channel patch clamp study of clonal human kidney …