Antigen presentation by Langerhans cells

BZ Igyártó, DH Kaplan - Current opinion in immunology, 2013 - Elsevier
Current opinion in immunology, 2013Elsevier
Langerhans cells and other skin-resident dendritic cells (DC) are required for the
development of cutaneous adaptive immune responses. In vivo experiments using mice with
selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that
each subset makes a unique contribution to the adaptive response. This review focuses on
the functional outcome of antigen presentation by Langerhans cells. Special attention is
given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts …
Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.
Elsevier