[HTML][HTML] Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling
Receptor activator of NF-κB ligand (RANKL) activates signaling pathways that regulate
osteoclast differentiation, function, and survival. The microphthalmia transcription factor
(MITF) is required for terminal differentiation of osteoclasts. To determine whether MITF
could be a target of RANKL signaling, a phosphospecific MITF antibody directed against
conserved residue Ser 307, a potential mitogen-activated protein kinase (MAPK) site, was
produced. Using this antibody, we could demonstrate that MITF was rapidly and persistently …
osteoclast differentiation, function, and survival. The microphthalmia transcription factor
(MITF) is required for terminal differentiation of osteoclasts. To determine whether MITF
could be a target of RANKL signaling, a phosphospecific MITF antibody directed against
conserved residue Ser 307, a potential mitogen-activated protein kinase (MAPK) site, was
produced. Using this antibody, we could demonstrate that MITF was rapidly and persistently …