[HTML][HTML] Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
H Hanafusa, J Ninomiya-Tsuji, N Masuyama… - Journal of Biological …, 1999 - ASBMB
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), a member of the mitogen-
activated protein kinase kinase kinase family, is suggested to be involved in TGF-β-induced
gene expression, but the signaling mechanism from TAK1 to the nucleus remains largely
undefined. We have found that p38 mitogen-activated protein kinase, and its direct activator
MKK6 are rapidly activated in response to TGF-β. Expression of dominant negative MKK6 or
dominant negative TAK1 inhibited the TGF-β-induced transcriptional activation as well as …
activated protein kinase kinase kinase family, is suggested to be involved in TGF-β-induced
gene expression, but the signaling mechanism from TAK1 to the nucleus remains largely
undefined. We have found that p38 mitogen-activated protein kinase, and its direct activator
MKK6 are rapidly activated in response to TGF-β. Expression of dominant negative MKK6 or
dominant negative TAK1 inhibited the TGF-β-induced transcriptional activation as well as …