Pathophysiology of cancer cachexia: much more than host–tumour interaction?

RJE Skipworth, GD Stewart, CHC Dejong, T Preston… - Clinical nutrition, 2007 - Elsevier
Cancer cachexia is a syndrome of progressive nutritional depletion which causes significant
morbidity and mortality in cancer patients. One of the main pathogenetic mechanisms
underlying cancer cachexia is a complex interaction between the host and the tumour.
Tumour cells interact with host cells within the tumour mass resulting in the production of
catabolic mediators which degrade host tissue. In addition, the host may mount an aberrant
metabolic response to the tumour. However, in recent years, it has also been understood …