[HTML][HTML] IL-36γ/IL-1F9, an innate T-bet target in myeloid cells

M Bachmann, P Scheiermann, L Härdle… - Journal of biological …, 2012 - ASBMB
By concerted action in dendritic (DC) and T cells, T-box expressed in T cells (T-bet, Tbx21) is
pivotal for initiation and perpetuation of Th1 immunity. Identification of novel T-bet-regulated
genes is crucial for further understanding the biology of this transcription factor. By
combining siRNA technology with genome-wide mRNA expression analysis, we sought to
identify new T-bet-regulated genes in predendritic KG1 cells activated by IL-18. One gene
robustly dependent on T-bet was IL-36γ, a recently described novel IL-1 family member …