[PDF][PDF] Selective versus total insulin resistance: a pathogenic paradox
MS Brown, JL Goldstein - Cell metabolism, 2008 - cell.com
MS Brown, JL Goldstein
Cell metabolism, 2008•cell.comMice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to
suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly
combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism,
Biddinger et al.(2008) show that mice with total hepatic insulin resistance exhibit
hyperglycemia without hypertriglyceridemia—a state paradoxically less severe than
selective insulin resistance.
suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly
combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism,
Biddinger et al.(2008) show that mice with total hepatic insulin resistance exhibit
hyperglycemia without hypertriglyceridemia—a state paradoxically less severe than
selective insulin resistance.
Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia—a state paradoxically less severe than selective insulin resistance.
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