[HTML][HTML] Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver
SH Koo, AK Dutcher, HC Towle - Journal of Biological Chemistry, 2001 - ASBMB
Transcription of a number of genes involved in lipogenesis is stimulated by dietary
carbohydrate in the mammalian liver. Both insulin and increased glucose metabolism have
been proposed to be initiating signals for this process, but the pathways by which these
effectors act to alter transcription have not been resolved. We have previously defined by
electrophoretic mobility shift assay a factor in nuclear extracts from rat liver, designated the
carbohydrate-responsive factor (Cho-RF), that binds to liver-type pyruvate kinase and S 14 …
carbohydrate in the mammalian liver. Both insulin and increased glucose metabolism have
been proposed to be initiating signals for this process, but the pathways by which these
effectors act to alter transcription have not been resolved. We have previously defined by
electrophoretic mobility shift assay a factor in nuclear extracts from rat liver, designated the
carbohydrate-responsive factor (Cho-RF), that binds to liver-type pyruvate kinase and S 14 …