[HTML][HTML] Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
JJ Lee, JE Lambert, Y Hovhannisyan… - The American journal of …, 2015 - Elsevier
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA)
synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16: 1n–7 to 16:
0 [SCD1 (16)] in plasma triacylglycerol FA has been used as an index to reflect liver SCD1
(16) activity and has been proposed as a biomarker of FA synthesis, although this use has
not been validated by comparison with isotopically measured de novo lipogenesis (DNL
Meas). Objective: We investigated plasma lipid 16: 1n–7 and FA indexes of elongation and …
synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16: 1n–7 to 16:
0 [SCD1 (16)] in plasma triacylglycerol FA has been used as an index to reflect liver SCD1
(16) activity and has been proposed as a biomarker of FA synthesis, although this use has
not been validated by comparison with isotopically measured de novo lipogenesis (DNL
Meas). Objective: We investigated plasma lipid 16: 1n–7 and FA indexes of elongation and …