Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
N Chalasani, CJ Gorski, MS Asghar, A Asghar… - Hepatology, 2003 - journals.lww.com
Abstract Cytochrome P450 2E1 (CYP2E1) plays an important role in the pathogenesis of
nonalcoholic steatohepatitis (NASH) in animal models, but its role in the pathogenesis of
human NASH is unclear. Therefore, we measured hepatic CYP2E1 activity and its correlates
in a cohort of nondiabetic patients with NASH (NDN) and controls to explore its role in the
pathogenesis of human NASH. Hepatic CYP2E1 activity was assessed using the oral
clearance (CL PO) of chlorzoxazone (CHZ) in 20 NDN and 17 age, gender, and body mass …
nonalcoholic steatohepatitis (NASH) in animal models, but its role in the pathogenesis of
human NASH is unclear. Therefore, we measured hepatic CYP2E1 activity and its correlates
in a cohort of nondiabetic patients with NASH (NDN) and controls to explore its role in the
pathogenesis of human NASH. Hepatic CYP2E1 activity was assessed using the oral
clearance (CL PO) of chlorzoxazone (CHZ) in 20 NDN and 17 age, gender, and body mass …