Relation of vitamin B12 and one-carbon metabolism to hydrocephalus in the rat
JC Woodard, PM Newberne - The Journal of Nutrition, 1966 - Elsevier
The purpose of this investigation was to examine the relationship of a number of factors
involved in 1-carbon metabolism to the induction of hydrocephalus in the rat. Animals raised
with a diet deficient in vitamin B 12 gave birth to young with congenital hydrocephalus. The
addition of an intestinal antibiotic, neomycin, to the dams' diets or the parenteral
administration of vitamin B 12 antagonists did not markedly increase the incidence of
congenital abnormalities. The incidence of congenital hydrocephalus was markedly …
involved in 1-carbon metabolism to the induction of hydrocephalus in the rat. Animals raised
with a diet deficient in vitamin B 12 gave birth to young with congenital hydrocephalus. The
addition of an intestinal antibiotic, neomycin, to the dams' diets or the parenteral
administration of vitamin B 12 antagonists did not markedly increase the incidence of
congenital abnormalities. The incidence of congenital hydrocephalus was markedly …