SCO-ping out the mechanisms underlying the etiology of hydrocephalus
MS Huh, MAM Todd, DJ Picketts - Physiology, 2009 - journals.physiology.org
MS Huh, MAM Todd, DJ Picketts
Physiology, 2009•journals.physiology.orgThe heterogeneous nature of congenital hydrocephalus has hampered our understanding of
the molecular basis of this common clinical problem. However, disease gene identification
and characterization of multiple transgenic mouse models has highlighted the importance of
the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review
how altered development and function of the SCO and vel cells contributes to
hydrocephalus.
the molecular basis of this common clinical problem. However, disease gene identification
and characterization of multiple transgenic mouse models has highlighted the importance of
the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review
how altered development and function of the SCO and vel cells contributes to
hydrocephalus.
The heterogeneous nature of congenital hydrocephalus has hampered our understanding of the molecular basis of this common clinical problem. However, disease gene identification and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus.
American Physiological Society