Short-chain acylation of lysine residues has recently emerged as a group of reversible
posttranslational modifications in mammalian cells. The diversity of acylation further
broadens the landscape and complexity of the proteome. Identification of regulatory
enzymes and effector proteins for lysine acylation is critical to understand functions of these
novel modifications at the molecular level. Here, we report that the MYST family of lysine
acetyltransferases (KATs) possesses strong propionyltransferase activity both in vitro and in …