[HTML][HTML] Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties
E Cancellotti, F Wiseman, NL Tuzi, H Baybutt… - Journal of Biological …, 2005 - ASBMB
N-Linked glycans have been shown to have an important role in the cell biology of a variety
of cell surface glycoproteins, including PrP protein. It has been suggested that glycosylation
of PrP can influence the susceptibility to transmissible spongiform encephalopathy and
determine the characteristics of the many different strains observed in this particular type of
disease. To understand the role of carbohydrates in influencing the PrP maturation, stability,
and cell biology, we have produced and analyzed gene-targeted murine models expressing …
of cell surface glycoproteins, including PrP protein. It has been suggested that glycosylation
of PrP can influence the susceptibility to transmissible spongiform encephalopathy and
determine the characteristics of the many different strains observed in this particular type of
disease. To understand the role of carbohydrates in influencing the PrP maturation, stability,
and cell biology, we have produced and analyzed gene-targeted murine models expressing …