Electrospray mass spectrometry of the glycosylinositol phospholipid of the scrapie prion protein.
N Stahl, MA Baldwin, SB Prusiner - 1991 - cabidigitallibrary.org
N Stahl, MA Baldwin, SB Prusiner
1991•cabidigitallibrary.orgThe electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform
of the scrapie prion protein is described. As well as the 3 forms of glycosylinositol
phospholipid (GPL) previously identified, a further two forms were identified by high
resolution tandem mass spectrometry that differed from the original forms by the addition of a
sialic acid. Electrospray mass spectrometry revealed 3 molecular species of GPL present at
both the+ 4 and+ 3 change states. Molecular masses were 2995.0, 3285.4 and 2832.1±1 …
of the scrapie prion protein is described. As well as the 3 forms of glycosylinositol
phospholipid (GPL) previously identified, a further two forms were identified by high
resolution tandem mass spectrometry that differed from the original forms by the addition of a
sialic acid. Electrospray mass spectrometry revealed 3 molecular species of GPL present at
both the+ 4 and+ 3 change states. Molecular masses were 2995.0, 3285.4 and 2832.1±1 …
Abstract
The electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform of the scrapie prion protein is described. As well as the 3 forms of glycosylinositol phospholipid (GPL) previously identified, a further two forms were identified by high resolution tandem mass spectrometry that differed from the original forms by the addition of a sialic acid. Electrospray mass spectrometry revealed 3 molecular species of GPL present at both the +4 and +3 change states. Molecular masses were 2995.0, 3285.4 and 2832.1±1 Da.
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