[HTML][HTML] FXYD5 protein has a pro-inflammatory role in epithelial cells
I Lubarski-Gotliv, C Asher, LA Dada, H Garty - Journal of Biological …, 2016 - ASBMB
The FXYD proteins are a family of small membrane proteins that share an invariant four
amino acid signature motif FXYD and act as tissue-specific regulatory subunits of the Na, K-
ATPase. FXYD5 (also termed dysadherin or RIC) is a structurally and functionally unique
member of the FXYD family. As other FXYD proteins, FXYD5 specifically interacts with the
Na, K-ATPase and alters its kinetics by increasing V max. However, unlike other family
members FXYD5 appears to have additional functions, which cannot be readily explained …
amino acid signature motif FXYD and act as tissue-specific regulatory subunits of the Na, K-
ATPase. FXYD5 (also termed dysadherin or RIC) is a structurally and functionally unique
member of the FXYD family. As other FXYD proteins, FXYD5 specifically interacts with the
Na, K-ATPase and alters its kinetics by increasing V max. However, unlike other family
members FXYD5 appears to have additional functions, which cannot be readily explained …
