[HTML][HTML] The interferon regulatory factor family in host defense: mechanism of action
K Ozato, P Tailor, T Kubota - Journal of Biological Chemistry, 2007 - ASBMB
Transcription factors of the interferon regulatory factor (IRF) family commands the entire type
I interferon (IFN) system from induction of IFNs to diverse IFN responses, thereby providing a
principal basis for host resistance against pathogens. However, the family has various
additional roles. Regulating the development of the immune system, IRFs shape the
establishment and execution of innate and adaptive immunity. IRFs also regulate growth
and differentiation of many cell types, thus playing a role in leukemia and other cancers. In …
I interferon (IFN) system from induction of IFNs to diverse IFN responses, thereby providing a
principal basis for host resistance against pathogens. However, the family has various
additional roles. Regulating the development of the immune system, IRFs shape the
establishment and execution of innate and adaptive immunity. IRFs also regulate growth
and differentiation of many cell types, thus playing a role in leukemia and other cancers. In …