Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice
TS Park, RL Panek, MD Rekhter, SB Mueller… - Atherosclerosis, 2006 - Elsevier
Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease
independent of cholesterol levels. A decrease of SM in lipoproteins is known to improve the
activities of lecithin: cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) in vitro.
Inhibition of SM biosynthesis may reduce lipoprotein SM content and thus improve
cholesterol distribution in lipoproteins by enhancing reverse cholesterol transport and
clearance of triglyceride-rich lipoproteins. To examine this hypothesis, ApoE KO mice were …
independent of cholesterol levels. A decrease of SM in lipoproteins is known to improve the
activities of lecithin: cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) in vitro.
Inhibition of SM biosynthesis may reduce lipoprotein SM content and thus improve
cholesterol distribution in lipoproteins by enhancing reverse cholesterol transport and
clearance of triglyceride-rich lipoproteins. To examine this hypothesis, ApoE KO mice were …