Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial
KB Margulies, AF Hernandez, MM Redfield, MM Givertz… - Jama, 2016 - jamanetwork.com
Importance Abnormal cardiac metabolism contributes to the pathophysiology of advanced
heart failure with reduced left ventricular ejection fraction (LVEF). Glucagon-like peptide 1
(GLP-1) agonists have shown cardioprotective effects in early clinical studies of patients with
advanced heart failure, irrespective of type 2 diabetes status. Objective To test whether
therapy with a GLP-1 agonist improves clinical stability following hospitalization for acute
heart failure. Design, Setting, and Participants Phase 2, double-blind, placebo-controlled …
heart failure with reduced left ventricular ejection fraction (LVEF). Glucagon-like peptide 1
(GLP-1) agonists have shown cardioprotective effects in early clinical studies of patients with
advanced heart failure, irrespective of type 2 diabetes status. Objective To test whether
therapy with a GLP-1 agonist improves clinical stability following hospitalization for acute
heart failure. Design, Setting, and Participants Phase 2, double-blind, placebo-controlled …