Protective effects of GLP-1 analogues exendin-4 and GLP-1 (9–36) amide against ischemia–reperfusion injury in rat heart

DP Sonne, T Engstrøm, M Treiman - Regulatory peptides, 2008 - Elsevier
Glucagon-Like Peptide-1 (GLP-1) is an incretin peptide secreted from intestinal L-cells,
whose potent plasma glucose-lowering action has prompted intense efforts to develop GLP-
1 receptor-targeting drugs for treatment of diabetic hyperglycemia. More recently, GLP-1 and
its analogues have been shown to exert cardiovascular effects in a number of experimental
models. Here we tested exendin-4 (Exe-4), a peptide agonist at GLP-1 receptors, and GLP-1
(9–36) amide, the primary endogenous metabolite of GLP-1 (both in the concentration range …