Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes

S Boudina, ED Abel - Physiology, 2006 - journals.physiology.org
S Boudina, ED Abel
Physiology, 2006journals.physiology.org
Cardiovascular disease is the primary cause of death in individuals with obesity and
diabetes. However, the underlying mechanisms for cardiac dysfunction are partially
understood. Studies have suggested that altered cardiac metabolism may play a role. The
diabetic heart is characterized by increased fatty acid oxidation, increased myocardial
oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms
for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of …
Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.
American Physiological Society