GLP-1-derived nonapeptide GLP-1 (28–36) amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes
E Tomas, V Stanojevic, JF Habener - Regulatory peptides, 2011 - Elsevier
BACKGROUND: Uncontrolled hepatic glucose production (gluconeogenesis), and
glycogenolysis, is a major contributor to the fasting hyperglycemia associated with type 2
diabetes. Here we report the discovery of a C-terminal nonapeptide (FIAWLVKGRamide)
derived from GLP-1 that suppresses glucose production and oxidative stress in isolated
mouse hepatocytes. The nonapeptide, GLP-1 (28–36) amide, was reported earlier to be a
major product derived from the cleavage of GLP-1 by the endopeptidase NEP 24.11 …
glycogenolysis, is a major contributor to the fasting hyperglycemia associated with type 2
diabetes. Here we report the discovery of a C-terminal nonapeptide (FIAWLVKGRamide)
derived from GLP-1 that suppresses glucose production and oxidative stress in isolated
mouse hepatocytes. The nonapeptide, GLP-1 (28–36) amide, was reported earlier to be a
major product derived from the cleavage of GLP-1 by the endopeptidase NEP 24.11 …