Nintedanib as a novel treatment option in hereditary haemorrhagic telangiectasia

E Kovacs-Sipos, D Holzmann, T Scherer… - Case …, 2017 - casereports.bmj.com
E Kovacs-Sipos, D Holzmann, T Scherer, MB Soyka
Case Reports, 2017casereports.bmj.com
A 70-year-old patient with known hereditary haemorrhagictelangiectasia (HHT) was seen
regularly in our outpatient clinic. He underwent multiple therapeutical interventions,
including both surgical and medical, for the treatment of recurrent epistaxis without
sustained success. Due to a concurrent diagnosis of idiopathic pulmonary fibrosis, treatment
with the tyrosine kinase inhibitor nintedanib was initiated, after which point the patient
reported a dramatic and unanticipated improvement in his epistaxis and skin telangiectasia …
A 70-year-old patient with known hereditary haemorrhagictelangiectasia (HHT) was seen regularly in our outpatient clinic. He underwent multiple therapeutical interventions, including both surgical and medical, for the treatment of recurrent epistaxis without sustained success. Due to a concurrent diagnosis of idiopathic pulmonary fibrosis, treatment with the tyrosine kinase inhibitor nintedanib was initiated, after which point the patient reported a dramatic and unanticipated improvement in his epistaxis and skin telangiectasia. On the basis of this case report, we propose that nintedanib may be a potential treatment option for refractory epistaxis in HHT.
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