[HTML][HTML] Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway
JJ Steinle, CJ Meininger, R Forough, G Wu… - Journal of Biological …, 2002 - ASBMB
The goals of this study were 2-fold: 1) to determine whether stimulation of Eph B4 receptors
promotes microvascular endothelial cell migration and/or proliferation, and 2) to elucidate
signaling pathways involved in these responses. The human endothelial cells used
possessed abundant Eph B4 receptors with no endogenous ephrin B2 expression.
Stimulation of these receptors with ephrin B2/Fc chimera resulted in dose-and time-
dependent phosphorylation of Akt. These responses were inhibited by LY294002 and ML-9 …
promotes microvascular endothelial cell migration and/or proliferation, and 2) to elucidate
signaling pathways involved in these responses. The human endothelial cells used
possessed abundant Eph B4 receptors with no endogenous ephrin B2 expression.
Stimulation of these receptors with ephrin B2/Fc chimera resulted in dose-and time-
dependent phosphorylation of Akt. These responses were inhibited by LY294002 and ML-9 …