[HTML][HTML] Small molecules can selectively inhibit Ephrin binding to the EphA4 and EphA2 receptors∗
R Noberini, M Koolpe, S Peddibhotla, R Dahl… - Journal of Biological …, 2008 - ASBMB
The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases
regulates a multitude of physiological and pathological processes. Despite the numerous
possible research and therapeutic applications of agents capable of modulating Eph
receptor function, no small molecule inhibitors targeting the extracellular domain of these
receptors have been identified. We have performed a high throughput screen to search for
small molecules that inhibit ligand binding to the extracellular domain of the EphA4 receptor …
regulates a multitude of physiological and pathological processes. Despite the numerous
possible research and therapeutic applications of agents capable of modulating Eph
receptor function, no small molecule inhibitors targeting the extracellular domain of these
receptors have been identified. We have performed a high throughput screen to search for
small molecules that inhibit ligand binding to the extracellular domain of the EphA4 receptor …