TGF-β family signaling in embryonic and somatic stem-cell renewal and differentiation

AC Mullen, JL Wrana - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
AC Mullen, JL Wrana
Cold Spring Harbor perspectives in biology, 2017cshperspectives.cshlp.org
Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate
and invertebrate models revealed the TGF-β family to be central regulators of tissue
morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions
in animal development, coordinate complex organogenesis, and contribute to tissue
homeostasis in the adult. Here, we focus on the role of the TGF-β family in mammalian stem-
cell biology and discuss its wide and varied activities both in the regulation of pluripotency …
Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-β family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.
cshperspectives.cshlp.org