[HTML][HTML] Prognostic significance of NPM1 mutations in the absence of FLT3–internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and …
F Ostronoff, M Othus, M Lazenby, E Estey… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
F Ostronoff, M Othus, M Lazenby, E Estey, FR Appelbaum, A Evans, J Godwin, A Gilkes…
Journal of Clinical Oncology, 2015•ncbi.nlm.nih.govPurpose Younger patients with acute myeloid leukemia (AML) harboring NPM1 mutations
without FLT3–internal tandem duplications (ITDs; NPM1-positive/FLT3-ITD–negative
genotype) are classified as better risk; however, it remains uncertain whether this favorable
classification can be applied to older patients with AML with this genotype. Therefore, we
examined the impact of age on the prognostic significance of NPM1-positive/FLT3-ITD–
negative status in older patients with AML.
without FLT3–internal tandem duplications (ITDs; NPM1-positive/FLT3-ITD–negative
genotype) are classified as better risk; however, it remains uncertain whether this favorable
classification can be applied to older patients with AML with this genotype. Therefore, we
examined the impact of age on the prognostic significance of NPM1-positive/FLT3-ITD–
negative status in older patients with AML.
Abstract
Purpose
Younger patients with acute myeloid leukemia (AML) harboring NPM1 mutations without FLT3–internal tandem duplications (ITDs; NPM1-positive/FLT3-ITD–negative genotype) are classified as better risk; however, it remains uncertain whether this favorable classification can be applied to older patients with AML with this genotype. Therefore, we examined the impact of age on the prognostic significance of NPM1-positive/FLT3-ITD–negative status in older patients with AML.
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