[HTML][HTML] A decade of research on the 17q12-21 asthma locus: piecing together the puzzle
MM Stein, EE Thompson, N Schoettler… - Journal of Allergy and …, 2018 - Elsevier
Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
Genotypes in the core region defined by the first genome-wide association study correlate
with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making
these prime candidate asthma genes, although recent studies have implicated gasdermin A
(GSDMA) distal to and post-GPI attachment to proteins 3 (PGAP3) proximal to the core
region as independent loci. We review 10 years of studies on the 17q12-21 locus and …
Genotypes in the core region defined by the first genome-wide association study correlate
with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making
these prime candidate asthma genes, although recent studies have implicated gasdermin A
(GSDMA) distal to and post-GPI attachment to proteins 3 (PGAP3) proximal to the core
region as independent loci. We review 10 years of studies on the 17q12-21 locus and …