[HTML][HTML] Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic …
Angiogenin (ANG) and ribonuclease 4 (RNASE4), two members of the secreted and
vertebrate-specific ribonuclease superfamily, play important roles in cancers and
neurodegenerative diseases. The ANG and RNASE4 genes share genetic regions with
promoter activities, but the structure and regulation of these putative promotes are unknown.
We have characterized the promoter regions, defined the transcription start site, and
identified a mechanism of transcription regulation that involves both RNA polymerase III (Pol …
vertebrate-specific ribonuclease superfamily, play important roles in cancers and
neurodegenerative diseases. The ANG and RNASE4 genes share genetic regions with
promoter activities, but the structure and regulation of these putative promotes are unknown.
We have characterized the promoter regions, defined the transcription start site, and
identified a mechanism of transcription regulation that involves both RNA polymerase III (Pol …