Genetic variability in susceptibility and response to toxicants
MC Miller III, HW Mohrenweiser, DA Bell - Toxicology letters, 2001 - Elsevier
Everyone has a unique combination of polymorphic traits that modify susceptibility and
response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous
and endogenous chemical toxins may be modified by inherited and induced variation in
CYP (P450), acetyltransferase (NAT) and glutathione S-transferase (GST) genes. We
observe that specific 'at risk'genotypes for GSTM1 and NAT1/2 increase risk for bladder
cancer among smokers. Genotypic and phenotypic variation in DNA repair may affect risk of …
response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous
and endogenous chemical toxins may be modified by inherited and induced variation in
CYP (P450), acetyltransferase (NAT) and glutathione S-transferase (GST) genes. We
observe that specific 'at risk'genotypes for GSTM1 and NAT1/2 increase risk for bladder
cancer among smokers. Genotypic and phenotypic variation in DNA repair may affect risk of …