[HTML][HTML] Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

P Song, N Zheng, Y Liu, C Tian, X Wu, X Ma… - Nature …, 2018 - nature.com
P Song, N Zheng, Y Liu, C Tian, X Wu, X Ma, D Chen, X Zou, G Wang, H Wang, Y Zhang…
Nature communications, 2018nature.com
Abstract Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious
disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic
interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-
viral immune response has been reported, but humoral involvement in viral pathogenesis is
poorly understood. Here we show defective serological responses to SFTSV is associated
with disease fatality and a combination of B-cell and T-cell impairment contribute to …
Abstract
Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response.
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