[HTML][HTML] Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis
DR McMillan, X Xiao, L Shao, K Graves… - Journal of Biological …, 1998 - ASBMB
Heat shock transcription factor 1 (HSF1) is a member of the vertebrate HSF family that
regulates stress-inducible synthesis of heat shock proteins (HSPs). Although the synthesis of
the constitutively expressed and inducible members of the heat shock family of stress
proteins correlates with increased cellular protection, their relative contributions in acquired
cellular resistance or" thermotolerance" in mammalian cells is presently unknown. We report
here that constitutive expression of multiple HSPs in cultured embryonic cells was …
regulates stress-inducible synthesis of heat shock proteins (HSPs). Although the synthesis of
the constitutively expressed and inducible members of the heat shock family of stress
proteins correlates with increased cellular protection, their relative contributions in acquired
cellular resistance or" thermotolerance" in mammalian cells is presently unknown. We report
here that constitutive expression of multiple HSPs in cultured embryonic cells was …