Genetic forms of hypopituitarism and their manifestation in the neonatal period

KS Alatzoglou, MT Dattani - Early human development, 2009 - Elsevier
The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial
expression of transcription factors and signalling molecules. Naturally occurring and
transgenic murine models have demonstrated a role for many of these molecules in the
aetiology of congenital hypopituitarism. These include the transcription factors HESX1,
PROP1, POU1F1, LHX3, LHX4, PITX1, PITX2, OTX2, SOX2 and SOX3. Mutations in any of …