Molecular basis of combined pituitary hormone deficiencies

LE Cohen, S Radovick - Endocrine Reviews, 2002 - academic.oup.com
LE Cohen, S Radovick
Endocrine Reviews, 2002academic.oup.com
Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to
the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in
formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise
sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling
molecules and transcription factors. Mutations in some of the pituitary-specific transcription …
Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke’s pouch. Intensified cell proliferation within Rathke’s pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.
Oxford University Press