[HTML][HTML] Clinical activity of the γ-secretase inhibitor PF-03084014 in adults with desmoid tumors (aggressive fibromatosis)
Journal of Clinical Oncology, 2017•ncbi.nlm.nih.gov
Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or
fibroblasts. In general, they are slow growing and do not metastasize; however, locally
aggressive desmoid tumors can cause severe morbidity and loss of function. Disease
recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors
highlight the need to develop effective systemic treatments for this disease. In this study, we
evaluate objective response rate after therapy with the γ-secretase inhibitor PF-03084014 in …
fibroblasts. In general, they are slow growing and do not metastasize; however, locally
aggressive desmoid tumors can cause severe morbidity and loss of function. Disease
recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors
highlight the need to develop effective systemic treatments for this disease. In this study, we
evaluate objective response rate after therapy with the γ-secretase inhibitor PF-03084014 in …
Abstract
Purpose
Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or fibroblasts. In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors can cause severe morbidity and loss of function. Disease recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatments for this disease. In this study, we evaluate objective response rate after therapy with the γ-secretase inhibitor PF-03084014 in patients with recurrent, refractory, progressive desmoid tumors.
ncbi.nlm.nih.gov