[HTML][HTML] The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

DL Davis, K Gable, J Suemitsu, TM Dunn… - Journal of Biological …, 2019 - ASBMB
Sphingolipids compose a lipid family critical for membrane structure as well as intra-and
intercellular signaling. De novo sphingolipid biosynthesis is initiated by the enzyme serine
palmitoyltransferase (SPT), which resides in the endoplasmic reticulum (ER) membrane. In
both yeast and mammalian species, SPT activity is homeostatically regulated through small
ER membrane proteins, the Orms in yeast and the ORMDLs in mammalian cells. These
proteins form stable complexes with SPT. In yeast, the homeostatic regulation of SPT relies …