Low glucocorticoid receptor (GR), high Dig2 and low Bcl-2 expression in double positive thymocytes of BALB/c mice indicates their endogenous glucocorticoid …
F Boldizsár, L Pálinkás, T Czömpöly, D Bartis… - Immunobiology, 2006 - Elsevier
Several studies have shown that of the four major thymocyte subsets, the CD4/CD8 double
positive (DP) thymocytes are the most sensitive to in vivo glucocorticoid hormone (GC)-
induced apoptosis. Our aim was to analyse fine molecular differences among thymocyte
subgroups that could underlie this phenomenon. Therefore, we characterised the
glucocorticoid hormone receptor (GR) expression of thymocyte subgroups both at the mRNA
and protein levels by real-time PCR and flow cytometry, and correlated these features to …
positive (DP) thymocytes are the most sensitive to in vivo glucocorticoid hormone (GC)-
induced apoptosis. Our aim was to analyse fine molecular differences among thymocyte
subgroups that could underlie this phenomenon. Therefore, we characterised the
glucocorticoid hormone receptor (GR) expression of thymocyte subgroups both at the mRNA
and protein levels by real-time PCR and flow cytometry, and correlated these features to …
