[HTML][HTML] Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the amino terminus of the hormone-binding domain
M Xu, KD Dittmar, G Giannoukos, WB Pratt… - Journal of Biological …, 1998 - ASBMB
The glucocorticoid receptor (GR) HBD must be bound to the protein chaperone hsp90 in
order to acquire the high affinity steroid binding conformation. Despite this crucial role of
hsp90, its binding site in GR remains poorly defined. Large portions of the GR HBD have
been implicated and no similarity has been established between steroid receptor HBDs and
the catalytic domains of the protein kinases (eg pp60 src, Raf) that also form stable
heterocomplexes with hsp90. Thus, it has been thought that some general property of the …
order to acquire the high affinity steroid binding conformation. Despite this crucial role of
hsp90, its binding site in GR remains poorly defined. Large portions of the GR HBD have
been implicated and no similarity has been established between steroid receptor HBDs and
the catalytic domains of the protein kinases (eg pp60 src, Raf) that also form stable
heterocomplexes with hsp90. Thus, it has been thought that some general property of the …