'NOTCHing up'the in vitro production of dendritic cells
M Guilliams, CL Scott - Trends in immunology, 2018 - cell.com
Trends in immunology, 2018•cell.com
Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s
from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble
in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying
DCs in vitro and for further developing autologous DC-based antitumor vaccinations.
from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble
in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying
DCs in vitro and for further developing autologous DC-based antitumor vaccinations.
Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.
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