[HTML][HTML] Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding …
CL Farr, Y Matsushima, AT Lagina, N Luo… - Journal of Biological …, 2004 - ASBMB
Functional interactions between mitochondrial DNA polymerase (pol γ) and mitochondrial
single-stranded DNA-binding protein (mtSSB) from Drosophila embryos greatly enhance the
overall activity of pol γ by increasing primer recognition and binding and stimulating the rate
of initiation of DNA strands (Farr, CL, Wang, Y., and Kaguni, LS (1999) J. Biol. Chem. 274,
14779–14785). We show here that DNA-binding mutants of mtSSB are defective in
stimulation of DNA synthesis by pol γ. RNAi knock-down of mtSSB reduces expression to< …
single-stranded DNA-binding protein (mtSSB) from Drosophila embryos greatly enhance the
overall activity of pol γ by increasing primer recognition and binding and stimulating the rate
of initiation of DNA strands (Farr, CL, Wang, Y., and Kaguni, LS (1999) J. Biol. Chem. 274,
14779–14785). We show here that DNA-binding mutants of mtSSB are defective in
stimulation of DNA synthesis by pol γ. RNAi knock-down of mtSSB reduces expression to< …