Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine
JK Badin, RS Bruning, M Sturek - Experimental gerontology, 2018 - Elsevier
Abstract Background Metabolic syndrome (MetS) and aging are prevalent risk factors for
coronary artery disease (CAD) and contribute to the etiology of CAD, including dysregulation
of Ca 2+ handling mechanisms in coronary smooth muscle (CSM). The current study tested
the hypothesis that CAD severity and CSM Ca 2+ dysregulation were different in MetS-
induced CAD compared to aging-induced CAD. Methods Young (2.5±0.2 years) and old
(8.8±1.2 years) Ossabaw miniature swine were fed an atherogenic diet for 11 months to …
coronary artery disease (CAD) and contribute to the etiology of CAD, including dysregulation
of Ca 2+ handling mechanisms in coronary smooth muscle (CSM). The current study tested
the hypothesis that CAD severity and CSM Ca 2+ dysregulation were different in MetS-
induced CAD compared to aging-induced CAD. Methods Young (2.5±0.2 years) and old
(8.8±1.2 years) Ossabaw miniature swine were fed an atherogenic diet for 11 months to …