Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release
AF Hofmann, DJ Mangelsdorf… - Clinical gastroenterology …, 2009 - cghjournal.org
Conjugated bile acids are absorbed from the terminal ileum by the combined action of an
apical sodium-dependent transporter that takes bile acids into the cell and a basolateral
transporter that takes bile acids out of the cell and into portal venous blood. The ileum was
recognized as the preferential site of bile acid absorption by Tappeiner 2 in 1878, and his
observations were confirmed repeatedly. In 1960, Lack and Weiner 3 used the everted gut
sac technique to show that conjugated bile acids moved uphill, against a concentration …
apical sodium-dependent transporter that takes bile acids into the cell and a basolateral
transporter that takes bile acids out of the cell and into portal venous blood. The ileum was
recognized as the preferential site of bile acid absorption by Tappeiner 2 in 1878, and his
observations were confirmed repeatedly. In 1960, Lack and Weiner 3 used the everted gut
sac technique to show that conjugated bile acids moved uphill, against a concentration …