Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence

RP Mattick, C Breen, J Kimber… - Cochrane database of …, 2014 - cochranelibrary.com
RP Mattick, C Breen, J Kimber, M Davoli
Cochrane database of systematic reviews, 2014cochranelibrary.com
Background Buprenorphine maintenance treatment has been evaluated in randomised
controlled trials against placebo medication, and separately as an alternative to methadone
for management of opioid dependence. Objectives To evaluate buprenorphine maintenance
compared to placebo and to methadone maintenance in the management of opioid
dependence, including its ability to retain people in treatment, suppress illicit drug use,
reduce criminal activity, and mortality.
Background
Buprenorphine maintenance treatment has been evaluated in randomised controlled trials against placebo medication, and separately as an alternative to methadone for management of opioid dependence.
Objectives
To evaluate buprenorphine maintenance compared to placebo and to methadone maintenance in the management of opioid dependence, including its ability to retain people in treatment, suppress illicit drug use, reduce criminal activity, and mortality.
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