Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation
CY Li, XL Zhang, EA Matthews, KW Li, A Kurwa… - Pain, 2006 - Elsevier
Mechanisms of chronic pain, including neuropathic pain, are poorly understood.
Upregulation of voltage-gated calcium channel (VGCC) α2δ1 subunit (Cavα2δ1) in sensory
neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute
to neuropathic pain. To investigate the mechanisms without the influence of other injury
factors, we have created transgenic mice that constitutively overexpress Cavα2δ1 in
neuronal tissues. Cavα2δ1 overexpression resulted in enhanced currents, altered kinetics …
Upregulation of voltage-gated calcium channel (VGCC) α2δ1 subunit (Cavα2δ1) in sensory
neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute
to neuropathic pain. To investigate the mechanisms without the influence of other injury
factors, we have created transgenic mice that constitutively overexpress Cavα2δ1 in
neuronal tissues. Cavα2δ1 overexpression resulted in enhanced currents, altered kinetics …