[HTML][HTML] Centroacinar cells: At the center of pancreas regeneration

RL Beer, MJ Parsons, M Rovira - Developmental biology, 2016 - Elsevier
Developmental biology, 2016Elsevier
The process of regeneration serves to heal injury by replacing missing cells. Understanding
regeneration can help us replace cell populations lost during disease, such as the insulin-
producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal
pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However,
whether CACs contribute to β-cell regeneration in adult mammals remains controversial.
Here we review the current understanding of the role of CACs as endocrine progenitors …
Abstract
The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals.
Elsevier