[HTML][HTML] Centroacinar cells: At the center of pancreas regeneration
RL Beer, MJ Parsons, M Rovira - Developmental biology, 2016 - Elsevier
RL Beer, MJ Parsons, M Rovira
Developmental biology, 2016•ElsevierThe process of regeneration serves to heal injury by replacing missing cells. Understanding
regeneration can help us replace cell populations lost during disease, such as the insulin-
producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal
pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However,
whether CACs contribute to β-cell regeneration in adult mammals remains controversial.
Here we review the current understanding of the role of CACs as endocrine progenitors …
regeneration can help us replace cell populations lost during disease, such as the insulin-
producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal
pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However,
whether CACs contribute to β-cell regeneration in adult mammals remains controversial.
Here we review the current understanding of the role of CACs as endocrine progenitors …
Abstract
The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals.
Elsevier