[HTML][HTML] Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus
The binding of extracellular ATP to the P2X 7 receptor opens an integral cation-permeable
channel; it also leads to membrane blebbing and, in certain immune cells, interleukin-1β
secretion and eventual death. The latter three effects are unique to the P2X 7 receptor; also
unique among P2X receptors is the long intracellular C terminus of the protein. We have
shown that the C-terminal domain of the P2X 7 receptor is responsible for the cell blebbing
phenotype. A screen for proteins that associate with the C-terminal domain of the P2X 7 …
channel; it also leads to membrane blebbing and, in certain immune cells, interleukin-1β
secretion and eventual death. The latter three effects are unique to the P2X 7 receptor; also
unique among P2X receptors is the long intracellular C terminus of the protein. We have
shown that the C-terminal domain of the P2X 7 receptor is responsible for the cell blebbing
phenotype. A screen for proteins that associate with the C-terminal domain of the P2X 7 …